Pawsitively Pain-Free: How NSAIDs Are Changing the Lives of Dogs 

As pet owners, we want our pets to enjoy happy, pain-free lives. Problems like arthritis, which can make it difficult for dogs to walk about comfortably, can unfortunately develop in older dogs. NSAIDs, or nonsteroidal anti-inflammatory medicines, have shown to be an effective remedy in such circumstances.

NSAIDs can be useful in treating pain and inflammation in dogs, but it’s important to speak with a doctor before giving them to your pet. A post by the U.S. Food & Drug Administration (FDA) stresses the importance of seeking expert advice from a veterinarian who can determine whether an NSAID is appropriate for your dog’s specific needs and condition.

In this article, we will explore how NSAIDs work, their potential side effects, and the latest advances in canine pain management.

The Mechanism of Action

NSAIDs work by inhibiting the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins, the chemicals that cause inflammation and pain. By blocking COX, NSAIDs can reduce inflammation, swelling, and pain in affected areas of the body. However, NSAIDs can also inhibit the production of beneficial prostaglandins, which can lead to unwanted side effects.

Selective COX inhibitors, also known as coxibs, are a newer class of NSAIDs that target only one form of the COX enzyme, COX-2. This makes them less likely to cause side effects such as gastrointestinal ulcers and bleeding. Some examples of coxibs used in veterinary medicine include deracoxib, firocoxib, and robenacoxib.

The Role and Benefits of NSAIDs

NSAIDs are commonly used to manage chronic pain in dogs, particularly those with osteoarthritis, hip dysplasia, and soft tissue injuries. By reducing inflammation and pain, NSAIDs can improve mobility, increase activity levels, and enhance the overall quality of life for dogs with chronic pain.

Quellin is one of the most popular NSAIDs on the market right now, and it contains carprofen as its active ingredient. Benefits of Quellin for pets include the following:

  • Reduced stiffness and soreness
  • Increased activity and exercise tolerance
  • Improved appetite and weight management
  • Enhanced overall quality of life
  • Non-addictive pain relief option

Combining NSAIDs With Other Therapies

PetRx has stated that NSAIDs can be used in combination with other therapies, such as physical therapy, weight management, and nutraceuticals, to maximize their effectiveness. For example, weight management can reduce the stress on joints, while physical therapy can improve mobility and reduce pain. Nutraceuticals such as glucosamine and chondroitin can also support joint health and reduce inflammation.

Potential Long-term Side Effects

While NSAIDs can provide significant relief to dogs suffering from pain and inflammation, they do come with some potential risks. Long-term use of NSAIDs can lead to kidney, liver, and gastrointestinal damage. To mitigate these risks, it’s crucial to use NSAIDs only as directed by a veterinarian and to monitor your dog for any signs of adverse effects.

According to a blog entry on petMD, dogs are more likely to experience negative effects with NSAIDs if they have an underlying liver or renal illness, digestive issues, blood clotting or bleeding disorders, blood pressure problems, or dehydration. In order for the vet to decide whether NSAIDs are appropriate and safe for your dog, it is crucial to let them know about any current health issues or symptoms that your dog may have.

Canine Pain Management: Recent Advancements 

Researchers have recently focused on developing safer and more effective NSAIDs for dogs. They are exploring the use of nanotechnology to improve the delivery of NSAIDs to affected tissues, which can reduce the risk of systemic side effects. Additionally, some researchers are investigating the use of gene therapy to target inflammation directly.

In addition to NSAIDs, there are a variety of emerging therapies and technologies being developed to manage pain in dogs. These include stem cell therapy, acupuncture, and wearable technology that can monitor a dog’s activity levels and detect changes in pain levels.

A recent post on WebMD reports that there is a lack of definitive evidence to prove the effectiveness of stem cell therapy in pets. However, anecdotal evidence from pet owners and veterinarians suggests that it may offer some potential benefits. Ongoing studies are currently underway to provide a more comprehensive understanding of the efficacy of stem cell therapy in pets.

Finally, it should be noted that while NSAIDs can be effective in managing pain, a holistic approach to pain management may be the most effective way to improve a dog’s overall quality of life. This approach includes proper nutrition, regular exercise, and other complementary therapies. 


In conclusion, managing chronic pain in dogs requires a holistic approach that goes beyond simply administering NSAIDs. While NSAIDs are effective in reducing inflammation and pain, they come with potential risks and must be used under the guidance of a veterinarian. Emerging therapies and technologies like stem cell therapy, nanotechnology, and wearable technology offer potential benefits but require further study. 

Ultimately, a comprehensive approach to pain management that includes proper nutrition, exercise, and complementary therapies can improve a dog’s overall quality of life. To ensure that their companions receive timely treatment, pet owners must be watchful and notify their veterinarian of any health problems or symptoms.
Pawsitively Pain-Free: How NSAIDs Are Changing the Lives of Dogs

As our beloved pet companions age and start to experience physical discomfort, as humans, we want to do what we can to make them comfortable. Until recently, however, pain relief options for animals have been limited.

NSAIDs (non-steroidal anti-inflammatory drugs) are changing this.

For years, veterinarians have prescribed medications that contain the same active ingredients as human drugs, such as ibuprofen, naproxen, aspirin, and meloxicam. But these were expensive and oftentimes only partially effective. Now, however, specially formulated NSAIDs for pets are becoming increasingly available and affordable.

NSAIDs are incredibly beneficial for pet owners and animals alike. They provide fast and sustained relief from inflammation, pain, and other symptoms associated with joint and chronic pain. They also allow for an improved quality of life for senior animals, allowing them to remain active for longer.

Additionally, due to their anti-inflammatory action, NSAIDs are also effective in treating conditions such as skin allergies, urinary tract infections, and even cancer. And unlike other drugs, NSAIDs do not narrow blood vessels, making them far less risky for the animal.

Ultimately, the introduction of NSAIDs is giving veterinary professionals a powerful and cost-effective tool to help our beloved four-legged friends. It is allowing them to live longer and more comfortable lives, and can help prevent costly visits to the vet due to pain-induced stress.

Without a doubt, NSAIDs are having a positive impact on our furry friends, and they will continue to change the lives of animals everywhere.